For patients undergoing IVF, there is one question that overshadows all others, “What is my chance of becoming pregnant and having a baby?” Success rates will be influenced by many factors, some of which are listed below. We can however, estimate your chance of success based on your age and fertility history. The age of the female partner is perhaps the single most important factor affecting a couple's chances of success with IVF. The probability of having a child declines after age 35 and falls significantly beyond 41, while miscarriage rates increase with age.
Factors affecting outcome:
'Live Birth' refers to the percentage of live births resulting from embryo transfers following IVF/ICSI treatment cycles and is the best measure to review a clinics success rates.
Cork Fertility’s live birth rates for 2014 for both IVF and ICSI treatment are represented in the graph below. For example, 46% of patients between the ages of 35 to 37 years who received IVF or ICSI treatment had a baby.
Note: 2014 is the most recent data available. Not all patients achieving pregnancy in 2015 will have delivered yet and the data is therefore incomplete.
Cork Fertility's success rates are benchmarked against the best in the UK and USA where reporting of results is mandatory and birth rates are transparent, our results are compared with SART for USA results and with ESHRE for European results.
Reporting of annual statistics is mandatory in the USA and SART data is compiled by CDC (Centers for Disease control and prevention). Below is a comparison live birth rates per embryo transfer for Cork Fertility versus SART (USA) rates for 2013. For example, 42.11% of Cork Fertility’s patients between the ages of 35 and 37 years who had a completed IVF or ICSI treatment cycle had a baby compared to 39.3% of patients treated in the USA.
Note: 2013 is the latest published SART data and results are based on live birth per embryo transfer.
Below is a comparison of 2011 live birth rates for Cork Fertility versus ESHRE (European Society of Human Reproduction and Embryology) rates across all age groups. Also included is a comparison of combined 2010 to 2014 live birth rates for Cork Fertility. For example, 31.5% of Cork Fertility patients who received IVF or ICSI treatment had a baby compared to the European average of 21.7% in 2011.
Note: 2011 is the latest published ESHRE data and results are based on live birth per egg collection.
Embryos that are not transferred during a fresh cycle can be vitrified (frozen) and stored for future use. The Vitrification process improves embryo survival on thawing and leads to higher live birth rates in comparison to traditional freezing methods. The latest live birth rate for Vitrification is 43.9% per frozen embryo transfer across all patient groups.
Read more on Vitrification here.
Blastocyst stage transfer involves culturing the embryos for 5-6 days in the laboratory before transfer back to the woman’s uterus. By observing the embryos for longer in an advanced culture system, we are more likely to identify the embryo(s) with greater implantation potential and therefore improve pregnancy rates. The live birth rate for the Blastocyst Programme is 64% across all patient groups in 2015.
Read more on Blastocyst here.
Elective Single Embryo Transfer (e-SET)
Due to advances in the science and practice of ART, elective Single Embryo Transfer (e-SET) using blastocyst stage embryos is a viable option for many patients who require IVF/ICSI treatment to conceive. Blastocyst embryos have a much higher implantation rate than 4 or 8 cell embryos, therefore fewer embryos are required to achieve pregnancy. When the laboratory carefully select one blastocyst embryo for transfer (e-SET) for patients undergoing their first IVF/ICSI treatment cycle, the live birth rate is 63% for patients of 40 years and younger.
It is important to understand the data presented when comparing 'success rates' between clinics. Often pregnancy rates can be quoted and these will always be higher than live birth rates. A clinic's success rate may also be influenced by its policies for cancelling cycles and by the number of embryos transferred.
Because live births can be calculated as a percentage of cycles started, egg collections or embryo transfers, it is very important to compare like with like when reviewing results. For example, the percentage of live births per egg collection is lower than the percentage of live births per embryo transfer. There are less egg collections than cycles started because some cycles are cancelled before egg collection.